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[Nebula]

Would weapons that have to be summoned first, such as Chrono's Oceanic Blades, count as a Signature Move or a Signature Weapon?

That would count as a weapon.

-- You may designate one weapon on your person as your Signature Weapon, which will remain with you and fully effective. If you do not have any weapons, you may instead designate a second Signature Move, as mentioned next.

My signature weapon would be the Proto Buster, which has like... 5 or 6 modes of fire ('uses' in our gameplay sense). How does that work?

In the event of weapons having multiple functions/uses, then if taken as a signature move they'd retain all their various uses. The same applies to variable moves, as a side note.

Would Bodypart Yogsothoth count as a natural weapon?

Yes.

What if your signature moves is healing?

What if you have healing super moves? Or regeneration super moves?

Then they won't work. Super moves would remain effective, however. Because they are Super Moves.