Impending Character Deliberations

[Handsome Jack]

Honestly, I think Law is the obvious choice, at least in terms of raw potential. Switching places with enemies and objects to avoid attacks. Debuffing peeps with swapping their body parts around. Lots of neat Move potential. But, like you inferred, a lot of his motivation is solidly grounded in the One Piece universe. Without a Doflamingo to put down, he wouldn't have a goal.

Volnutt might be too similar to X to even be an option, but I suppose if Alex thinks he's different enough to be a separate dude, it must be fine. I'm a fan of Megaman, but I worry he and Vile might go the same way Colonel did and you'll end up switching them out down the line.

You already got a couple "evil" dudes, so I'd personally shy away from anything similar to them. Kira and Vile, in terms of what you'll likely end up doing with them, would likely have a lot of similarity with Wesker and Anderson.

Roger, I think, would be an excellent choice for you. He's solidly neutral in how he views the world (giant robots destroying the city aside), and he'll be able to find new motivation in the OV pretty quickly. He's also different from the peeps you already write, so you don't hafta worry about rehashing too much.